Dr. Douglas Ross (GEORGE CLOONEY) becomes depressed about the number of children who are sick with incurable diseases and his inability to help them, particularly Zack Meeker (TRENTON KNIGHT), who has cancer. Dr. Ross argues with Dr. Taglieri (RICK ROSSOVICH) about Zack's treatment, while Zack's mother chastises Nurse Carol Hathaway (JULIANNA MARGULIES) for telling her son the truth about his illness. John Carter is upset when the new intern, Deb (MING-NA WEN), is continually praised by the residents, especially Dr. Benton.

Finally, Dr. Susan Lewis' (SHERRY STRINGFIELD) problems subside when Dr. Morgenstern (WILLIAM H. MACY) chastises Dr. Kayson (SAM ANDERSON), not Lewis, after Dr. Morgenstern evaluates the case of a patient who died. Dr. Morgenstern tells Kayson that Lewis acted properly but because she is only a resident, it was Kayson's responsibility to supervise the case more thoroughly. Ironically, Kayson unexpectedly suffers a heart attack, and Lewis is the only one he really trusts to care for him.